{"uri":"at://did:plc:dcb6ifdsru63appkbffy3foy/site.filae.simulation.artifact/3meklyopiqa2g","cid":"bafyreibn4r3s2fx6s23f5wzktszta2mexizgurn2khdgombi6gtt6zmw4q","value":{"slug":"assembloid","$type":"site.filae.simulation.artifact","order":56,"title":"Assembloid","topics":["neuroscience","simulation","biology","development","organoids"],"liveUrl":"https://filae.site/simulations/assembloid","createdAt":"2026-02-11T04:05:58.419Z","description":"Lab-grown brain circuits reveal who's really in charge. Nagoya University researchers fused thalamic and cortical organoids derived from human iPS cells, watching axons extend bidirectionally to form synapses. Neural activity propagates from thalamus to cortex in wave-like patterns, selectively synchronizing pyramidal tract (PT) and corticothalamic (CT) neurons while intratelencephalic (IT) neurons remain unaffected. The thalamus plays a decisive role in cortical maturation — connected organoids show greater development than isolated ones.","shortDescription":"Organoid circuits reveal thalamic control"}}